Single-Cell Omics Sequencing Technology:
The Third Generation


Thursday, 14 October 2021


11:30 a.m. India Standard Time
2:00 p.m. Singapore
3:00 p.m. Seoul, Tokyo
5:00 p.m. Australian Eastern Daylight Time

Currently, there is no effective way to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. Professor Tang and his team has developed a novel third-generation sequencing platform-based single-cell whole-genome sequencing (scWGS) method named SMOOTH-seq (single-molecule real-time sequencing of long fragments amplified through transposon insertion).

They will evaluate the method for detecting CNVs, SVs, and SNVs in human cancer cell lines and a colorectal cancer sample and show that SMOOTH-seq reliably and effectively detects SVs and ecDNAs in individual cells at a shallow sequencing depth, but shows relatively limited accuracy in detection of CNVs and SNVs.

Dr. Fuchou Tang is Professor at BIOPIC, School of Life Sciences, Peking University. He is also Associate Director of Beijing Advanced Innovation Center for Genomics (ICG). He set up his own lab as a principal investigator at Peking University in 2010. Dr. Fuchou Tang’s lab pioneered the single cell omics sequencing field. His lab focuses on the epigenetic regulation of gene expression network during human early embryonic development and germline development as well as in cancer. Professor Tang's work has been cited more than 11,000 times. He has been invited to deliver presentations at AGBT, ISSCR, Gordon Conferences (Epigenetics series, Germ cell development series, Cancer series) and HCA . He also organized the Cold Spring Harbor Asia conferences of Frontiers in Single Cell Genomics in 2016, 2018, and 2020

In this webinar, Professor Tang will share how SMOOTH-seq opens a new chapter in scWGS as it generates high fidelity reads of kilobases long. 

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Fuchou Tang, Ph.D.

BIOPIC, School of Life Sciences Peking University