A HiFi View:
Sequencing the Gut Microbiome
with Highly Accurate Long Reads

For Research Use Only. Not for use in diagnostics procedures.
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Learn how researchers are using PacBio HiFi sequencing to overcome common challenges in microbiome research, including ambiguous taxonomic assignments and culture-resistant bacteria.
Dr. Ashby starts the webinar off with a brief update on PacBio’s metagenomics solutions on the Sequel II System. Then, Dr. Ma, University of Maryland School of Medicine, discusses her work using long read sequencing to identify high-resolution microbial biomarkers associated with leaky gut syndrome in premature infants. Finally, Dr. Weinstock, The Jackson Laboratory, wraps things up by talking about the potential of highly accurate long reads to enable strain-level resolution of the human gut microbiome by resolving intraspecies variation in multiple copies of the 16S gene.

Watch this on-demand webinar to understand:

  • The potential of long reads for generating reference quality metagenome-assembled genomes for unculturable species
  • The higher level of resolution available with full-length 16S sequencing versus shorter amplicons and the utility of this information for answering biological questions
  • The key strengths of HiFi sequencing for characterizing metagenomes


Bing Ma, Ph.D.
Research Associate
Institute for Genome Sciences and Department of Microbiology and Immunology
University of Maryland School of Medicine

George Weinstock, Ph.D.
Principal Investigator
The Weinstock Lab, The Jackson Laboratory


Meredith Ashby, Ph.D.
Director, Strategic Marketing