Highly Accurate SMRT Sequencing for Gene Editing Applications

For Research Use Only. Not for use in diagnostics procedures.
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Current approaches to optimizing vector integrity for gene editing are insufficient. Gene editing protocols can benefit from long read sequencing at multiple stages. In this webinar we will offer an update on improvements to SMRT Sequencing technology and look at how they are being applied from early QC steps in AAV preps to looking at on/off target effects with greater resolution.
 
ATTENDEE TAKEAWAYS: 

  • Long reads give a much more comprehensive understanding of vector diversity
  • Long reads provide greater understanding of on target changes that cannot be seen with other sequencing methods due to read-length limitations or amplification biases
  • PacBio’s innovative, highly accurate technology addresses sample heterogeneity and offers simple / flexible workflows


SPEAKERS:

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Date: Tuesday, November 19, 2019
Time: 10:00 a.m. PST
1:00 p.m. EST
6:00 p.m. GMT
Andres Larrea, Ph.D.
Senior Manager, Field Business Development
PacBio
Phillip W.L. Tai, Ph.D.
Assistant Professor
University of Massachusetts Medical School
Dr. Tai is a Research Instructor at the University of Massachusetts Medical School (UMMS), in Worcester, MA.  He graduated from UC Berkeley (BA, Molecular and Cellular Biology), and the University of Washington (PhD, Biochemistry). His interests are in the mechanisms of gene regulation and transcriptional control of eukaryotic development genes. Dr. Tai’s current research in the laboratory of Dr. Guangping Gao, regards the development of next-gen sequencing methodologies to profile AAV vector genome quality, and the discovery and characterization of natural AAV capsid isolates for vectorization and gene therapy.
Dr. Larrea is a member of our Field Business Development team covering the Americas. He graduated from Florida State University (BS, Chemistry) and the University of Miami (PhD, Biochemistry and Molecular Biology). After a brief post-doctoral fellowship at the NIEHS/NIH where he applied NGS to dissecting the eukaryotic replication fork he joined Pacific Biosciences. Since joining PacBio in 2010 he has held several roles in support and sales looking to expand applications of SMRT sequencing in research, translational and applied labs.