Smoking Out Structural Variants in the Cannabis Genome

For Research Use Only. Not for use in diagnostics procedures.
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The legal California cannabis market is expected to be larger than the top 5 agricultural products combined in that state due to its fast growth and diverse use in fiber, food, and pharmaceutical generation. Unlike many outdoor grown crops, THCA and CBDA dominant cannabis strains are predominantly grown indoors at high expense (>$500/pound), placing an intense focus on the genetics of yield enhancement.

As a contribution to those efforts, Medicinal Genomics recently published the most comprehensive and complete cannabis genome assembly of a Type II (THCA and CBDA producing) plant known as Jamaican Lion. This work revealed a very complex tandem array of over 30 cannabinoid synthase genes separated by 30 kb, 60 kb & 90 kb long terminal repeats that are likely playing a role in gene duplication and enhanced expression.

To more completely characterize variants associated with cannabinoid synthase gene structures, we sequenced Type I, II, and III plants with PacBio long reads and identified type-specific structural variants.
Join our speakers as they share the latest advances in cannabis genomics, including:

  • How PacBio long-read sequencing enables high-quality genomics research in plants
  • High-quality annotation of the cannabis reference genome using full-length transcript sequencing
  • New insights into cannabinoid synthesis across different types of cannabis plants


Date: Tuesday, June 18, 2019
Time: 9:00 a.m. PDT
12:00 p.m. EDT
5:00 p.m. BST
Sarah Kingan, Ph.D.
Staff Scientist, Bioinformatics
We look forward to your participation as you learn about SMRT Sequencing!
Kevin McKernan
Founder and Chief Science Officer
Medicinal Genomics