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AGBT workshop: Revealing the Unknowns in Medical Research with Long-Read SMRT® Sequencing 

Join PacBio & Roche for our workshop featuring scientists sharing new insights into complex single genes, complete genomes, and rapidly evolving viruses using SMRT Sequencing.  Speakers will also discuss their visions for the eventual use of the technology for precision medicine.
Neil Gunn, President, Roche Sequencing
Michael Hunkapiller, President and Chief Executive Officer, PacBio
Towards Precision Medicine
Euan Ashley, MRCP, DPhil, Stanford University
Leveraging SMRT Sequencing Technology for Developing Niche Assays with Diagnostic Potential
Robert P. Sebra, Ph.D., Icahn School of Medicine at Mount Sinai
Deeply Sequencing Entire Genes from Rapidly Evolving Viruses
Ben Murrell, Ph.D., University of California, San Diego 
Clinical SMRT Sequencing - From Single Genes to Complete Genomes
Ulf Gyllensten, Ph.D., Uppsala University

Friday, February 12th

12:00 p.m. – 2:00 p.m., EST

For Research Use Only. Not for use in diagnostics procedures. © Copyright 2016 by Pacific Biosciences of California, Inc. All rights reserved


Friday, February 12
SplitThreader: A Graphical Algorithm for the Historical Reconstruction of Highly Rearranged and Amplified Cancer Genomes
Maria Nattestad, Cold Spring Harbor Laboratory
7:50 p.m. – 8:10 p.m.
Concurrent Session: Informatics
Mediterranean Salons 6-8

Evolving Approaches to Reference Assembly Improvement
Valerie Schneider, National Center for Biotechnology Information
7:50 p.m. – 8:10 p.m.
Concurrent Session: Biology
Mediterranean Ballroom/General Session Room

The First African Reference Genome Assembly
Karen Meltz Steinberg, Washington University School of Medicine
9:10 p.m. – 9:30 p.m.
Concurrent Session:  Informatics
Mediterranean Salons 6-8

Saturday, February 13

Addressing Complex Diseases and Hidden Heritability with the Sequel System
Jonas Korlach, PacBio
3:10 p.m. – 3:30 p.m.
Plenary Session: Technology II
Mediterranean Ballroom

Long-read Sequence Assembly of the Gorilla Genome
Christopher Hill, University of Washington
3:50 p.m. – 4:10 p.m.
Plenary Session: Technology II
Mediterranean Ballroom

#103: Meta-Methylome of Human Gut Microbiome using SMRT Sequencing
Yoshihiko Suzuki et al., University of Tokyo
#105: Low-Input Long-Read Sequencing for Complete Microbial Genomes and Metagenomic Community Analysis
Cheryl Heiner et al.,  PacBio
#203: Unprecedented Characterization of a Human Trio for New Genomic Reference Materials
Justin Zook et al., National Institute of Standards and Technology
#607: Cancer Genome Assembly and Structural Variant Detection with Bionano Optical Mapping and Pacific Biosciences Long Reads
Sara Goodwin et al., Cold Spring Harbor Laboratory
#703: With SMRT Sequencing Immune Regions Are No Longer Incomprehensible
Swati Ranade et al., PacBio
#709: Generation of a Genetic Variant Database Using Population-
Based Human Reference Genomes the 1000 Swedes Genome Project
Ulf Gyllensten et al., Uppsala University
#803: De Novo Transcriptome Assembly and Gene Annotation of Critically Endangered Spix’s Macaw: RNA-Seq vs Iso-Seq
Iman Al-Azwani  et al., Weill Cornell Medical College in Qatar
#811: Characterization of Splice Variants in Neuronal Tissues Using Targeted PacBio Sequencing.
Olivier Fedrigo et al, Duke University
#1005: Improving Existing Reference Genomes: Efforts at National Institute of Genetics
Asao Fujiyama et al., National Institute of Genetics (NIG)
#1007: Sequencing the Endangered Saimaa Ringed Seal (Pusa hispida saimensis) Genome
Lars Paulin et al., University of Helsinki
#1109: Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica using Single Molecule, Real-Time Sequencing
Maria Hoffmann et al., Center for Food Safety and Nutrition

Thursday, February 12, 5:00 p.m – 7:00 p.m.
Coquina North/South

#1209: Chromosomal-Scale and Targeted Haplotype Assembly using Long Range Data from TLA and SMRT Sequencing
Lawrence Hon et al.,  PacBio
#1301: Application and Assessment of Short and Long Read DNA and RNA Sequencing Technologies in the De novo Assembly of a Large Size Genome: The Olive Fruit Fly
Haig Djambazian et al., McGill University
#1303: Comparative Analysis of PacBio Libraries Reveals Non-Stochastic Biases in Sites of DNA Nicking
Ethan Alexander Garcia Baker et al., Sage Science
#1307: An Improved Circular Consensus Algorithm with an Application to Detection of HIV-1 Drug-Resistance Associated Mutations (DRAMs)
Lance Hepler et al., PacBio
#1403: SMRT Sequencing for the Detection of Low-Frequency Somatic Variants
Steve Kujawa et al., PacBio

#1605: New Approaches to Rescue Poorly Performing PacBio Libraries by Quantifying and Repairing Single Stranded DNA Nicks
Senem Eskipehlivan et al., Cold Spring Harbor Laboratory
#1803: Using PacBio Sequencing as a Synthetic Biology Error Analysis Tool
Robert Morey et al., Synthetic Genomics
#1809: Long-Read Assembly of the Aedes aegypti Aag2 Cell Line Genome Resolves Ancient Endogenous Viral Elements
Matthew Seetin et al., PacBio
#1905: RNA Isoform and Fusion Discovery on the Pacific Biosciences Platform using an Efficient and Robust Method for Normalizing Transcriptome Samples
Casey Jowdy et al., Cofactor Genomics
#2203: A Human Diploid Methylome Using SMRT Read Kinetics Data
Yuta Suzuki et al., University of Tokyo

#102: Profiling the Microbiome in Fecal Microbiota Transplantation using Circular Consensus and Single Molecule, Real-Time Sequencing
Richard Hall et al., PacBio
#106: Minimization of Chimera Formation in Full-Length 16S PCR Amplification
Cheryl Heiner et al., PacBio
#206: Highly Sensitive And Cost-Effective Detection Of BRCA1 And BRCA2 Cancer Mutations In FFPE Samples Using Multiplicom’s MASTR Technology & Single-Molecule, Real Time (SMRT®) Sequencing
Jurgen Del Favero et al., Multiplicom
#212: Finishing Two Bacterial Genomes on a Single SMRT Cell
Michael Quail et al., Wellcome Trust Sanger Institute
#308: Application Specific Barcoding Strategies for SMRT Sequencing
Primo Baybayan et al., PacBio
#410: An Optimized Library Construction Workflow for Long-Read Sequencing of the Mosquitos Genome
Adriana Geldart et al., Kapa Biosystems

#1004: Comparison of Various Genome Assemblies for the Heterozygous Date Palm
Lisa S. Mathew et al., Weill Cornell Medical College in Qatar

#1006: Genome Sequence of the Lesser Grain Borer, Rhyzopertha dominica
Brenda Oppert et al., USDA ARS Center for Grain and Animal Health Research

Friday, February 13, 4:45 p.m. – 6:45 p.m.
Coquina North/South

#1104: The Lamprey Genome: Deep Insights, Deep Challenges
Jeramiah J. Smith et al., University of Kentucky
#1106: De Novo Assembly of Medaka Fish Genomes Using SMRT Sequencing
Shinichi Morishita et al., University of Tokyo
#1204: Un-zipping Diploid Genomes – Revealing All Kinds of  Heterozygous Variants From Comprehensive Haplotig Assembly
Jason Chin et al., PacBio
#1310: Accurate Detection of SV Using Long Reads
Fritz Sedlazeck et al., Cold Spring Harbor Laboratory
#1408: Comparative Analysis of Somatic Fusion Gene Detection using Short Read and Long Read Sequencing
Chetanya Pandya et al., Icahn School of Medicine at Mount Sinai
#1502: Single-Molecule Long-Read Sequencing for Rapid Validation of Somatic Mutations in Cancer Genomics
Andrew Uzilov et al., Icahn School of Medicine at Mount Sinai
#2006: A Faster, Streamlined and Automatable Library Preparation Method for Pacific Biosciences SMRT Sequencing using Kapa Hyperprep
Toumy Guettouche et al., Roche Sequencing Unit


Visit our Hospitality Suite: Del Lago #2
Stop by the PacBio Lounge to see the new Sequel System, enjoy some coffee in a relaxed atmosphere, and recharge your devices (& yourself) daily.

Annual Beach Volleyball Outing
Early risers join us at the sand courts next to the Quench Poolside Bar and Grill at 7:30 a.m. on Thursday and Friday. Drinks and snacks will be provided.

Join us Friday Evening
Stop by the Fairway Lawn to enjoy liquid refreshments and lively conversations under the stars along with our fellow partners in life science exploration: 

Coquina North
Lunch will be provided

SD-18: DNAnexus, the Global Network for Genomic Medicine
Singer Ma, DNAnexus