Highly accurate HiFi reads for discovery, design, and manufacturing of AAV
gene therapy

Gene therapy is at an inflection point and experiencing tremendous growth. High accuracy and complete visibility are critical to the success of novel vector discovery, vector design, and manufacturing quality control for gene therapy products. HiFi sequencing is the ideal solution due to its ability to sequence full length AAV genomes at high accuracy, which allows for detection of fragmentation, mutations, and large structural events. Short reads, qPCR, and less accurate long-read technology can miss important changes that may be present in the AAV sequence, potentially affecting the safety and efficacy of gene therapy products.

Join us for this webinar to learn how experts in the field of gene therapy are using HiFi reads for better and more efficient vector design and quality control.

Watch the recording to:

  • Understand the challenges of AAV sequencing and the unique advantages of using PacBio long reads to address these unmet needs
  • Hear how biopharmaceutical researchers are using highly accurate HiFi reads for vector discovery, design, and quality control
  • Learn about the PacBio AAV solution and analyses

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Author, Affiliation

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Terrence Hanscom, PhD

Scientist, Homology Medicines, Inc.


Donald Selby, PhD

Principal Scientist, Homology Medicines, Inc.

Liz Tseng, PhD

Associate Director, Product Marketing, PacBio

Host and moderator
Trang Dahlen

Director, Emerging Applications, PacBio

Democratizing Genome Assembly and Annotation

Ted Kalbfleisch, Ph.D., Associate Professor, University of Kentucky

Molecular Genetic Applications Enabled by Platinum Quality Reference Genome Assemblies in Octoploid Strawberry

Mitchell Feldmann, Ph.D., Postdoctoral Fellow, University of California, Davis.